Abstract Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress.However, the molecular mechanisms by which p53 controls gene transcription are not completely understood.Here, we uncover the critical role of spatio-temporal genome architecture in this process.We demonstrate that p53 drives di
In this study, three high-resolution gridded rainfall datasets, viz., Integrated Multi-Satellite Retrievals for Global Precipitation Measurement (IMERG), Modern-Era Retrospective Analysis for Research and Applications 2 (MERRA-2), and Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN) have been col
In this paper, I address the vital civic principle that democracies cannot exist without informed citizens and that education itself must be about more than training and is essential to creating click here critical and engaged citizens.Such an understanding is imperative at a time when democracy is under siege all over the globe.As an example of bo
Trema orientale (L.) Blume is an important medicinal plant with multiple applications for treating several disease conditions.This study compiled published data on botanical, traditional uses, phytochemistry, pharmacology, and antimicrobials, coupled with discussing the conservation and domestication potential of T.orientale.Data were sourced from
An analytical model is developed to examine a low impulsive projectile impact on a fully clamped sandwich beams by considering the coupled responses of the core and the face sheets.Firstly, based on the dynamic properties of foam cores, the sandwich beam is modeled as two rigid perfectly-plastic popularfilm.blog beams connected by rigid perfectly-p